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dc.contributor.authorNDUKA, E.U.O.-
dc.date.accessioned2018-08-30T09:28:39Z-
dc.date.available2018-08-30T09:28:39Z-
dc.date.issued1981-01-
dc.identifier.urihttp://adhlui.com.ui.edu.ng/jspui/handle/123456789/12-
dc.descriptionA THESIS IN THE DEPARTMENT OF CHEMICAL PATHOLOGY, Submitted to the Faculty of Basic Medical Sciences and Pharmacy, College of Medicine, in partial fulfillment of the requirements for the degree of Doctor of Philosophy, University of Ibadan, Nigeria.en_US
dc.description.abstractThe response of the rat testis in vitro to gonadotropin and prostagladin El stimulation of testosterone secretion at different stages of rat development was studied. The technique employed involved the incubation of thecapsulated rat testis and the estimation of the secretion of testosterone by radioimmunoassay. The effects of the following factors on this process were also examined: (1) Low protein diet; (2) Drug (chloroquine) therapy. Studies of the basal levels of testosterone and PGE1 in these animals were supplemented by histologic evaluations. Based on the correlation of body and testis weights blood levels of testosterone and leydig cell development with age, the growth and development of the rat was found to be characterised in three distinct phases; these are the prepubertal, pubertal and postpubertal periods. The prepubertal period was found to be a period of minimal growth during which the circulating testosterone levels increasing from 0. 43±0.04nmol/L at 15 days to 1.24±043nmol/L at day 40. Also a gradual increase in basal secretory capacity of the rat testis occurred from 2.42±0.38nmolT/3hr./Testis at day 15 to 4.0.1±0.54nmolT/3hr./Testisen_US
dc.language.isoenen_US
dc.subjectPROSTAGLANDINen_US
dc.subjectGONADOTROPIN STIMULATIONen_US
dc.subjectTESTOSTERONE SECRETIONen_US
dc.subjectRAT TESTISen_US
dc.titlePROSTAGLANDIN AND GONADOTROPIN STIMULATION OF TESTOSTERONE SECRETION IN THE RAT TESTISen_US
dc.typeThesisen_US
Appears in Collections:Theses in Chemical Pathology

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