Inhibition of erythrocyte membrane Ca 2 + -pumping ATPase of hypertensive humans by nifedipine, a calcium entry blocker

Olorunsogo, O. O; Onatola, O. O; Lawal, S. O. A; Bababunmi, E. A; Falase, A. O; Okunade, W. G

Please use this identifier to cite or link to this item: http://adhlui.com.ui.edu.ng/jspui/handle/123456789/1733

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DC Field	Value	Language
dc.contributor.author	Olorunsogo, O. O	-
dc.contributor.author	Onatola, O. O	-
dc.contributor.author	Lawal, S. O. A	-
dc.contributor.author	Bababunmi, E. A	-
dc.contributor.author	Falase, A. O	-
dc.contributor.author	Okunade, W. G	-
dc.date.accessioned	2022-01-10T10:01:25Z	-
dc.date.available	2022-01-10T10:01:25Z	-
dc.date.issued	1991	-
dc.identifier.issn	1116-4077	-
dc.identifier.uri	http://adhlui.com.ui.edu.ng/jspui/handle/123456789/1733	-
dc.description.abstract	Nifedipine, a 1,4-dihydropyridine antihypertensive drug, inhibited the basal activity of erythrocyte C a 2 +, Mg 2 + -ATPase of hypertensive individuals in a concentration-dependent manner. About 5 0 % inhibition was obtained at nifedipine concentrations ^ 300 µᴍ. The extent of inhibition of the ATPase action was increased in the presence of calmodulin. Maximal inhibition at 400 µᴍ was 76%. Furthermore, the activity of the partially trypsinized enzyme was inhibited by about 5 0 % by 300 µᴍ nifedipine. Similar results were obtained with membranes from normotensive individuals. These findings suggest that nifedipine could prevent C a 2 + -pumping by the erythrocyte C a 2 +, M g 2 + -ATPase	en_US
dc.description.sponsorship	College of medicine, University of Ibadan	en_US
dc.language.iso	en	en_US
dc.publisher	Blackwell Scientific Publications	en_US
dc.relation.ispartofseries	Afr. J. Med. med. sci.1991:20;61-65;	-
dc.subject	Nifedipine	en_US
dc.subject	Hypertension	en_US
dc.subject	Erythrocyte	en_US
dc.subject	Calcium	en_US
dc.title	Inhibition of erythrocyte membrane Ca 2 + -pumping ATPase of hypertensive humans by nifedipine, a calcium entry blocker	en_US
dc.type	Article	en_US
Appears in Collections:	African Journal of Medicine and Medical Sciences

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