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dc.contributor.authorOlorunsogo, O.O-
dc.contributor.authorLawal, S.O.A-
dc.contributor.authorFalase, A.O-
dc.contributor.authorOunade, W.G-
dc.date.accessioned2022-01-25T13:48:56Z-
dc.date.available2022-01-25T13:48:56Z-
dc.date.issued1991-
dc.identifier.citationAfr J Med Med Sci. 1991, 20(2): 75-82.en_US
dc.identifier.issn1116-4077-
dc.identifier.urihttp://adhlui.com.ui.edu.ng/jspui/handle/123456789/1789-
dc.description.abstractAn assessment of the ATPase functions of erythrocyte membrane of newly identified subjects having essential hypertension shows that Na +, K+ -ATPase activity is higher in normal membranes than in membranes of individuals with essential hypertension. A study of the dependence of the enzyme on ATP in the presence of non-limiting concentrations of Na+ (120 mM) and Mg2 + (3 mM) shows that the pump in the membranes of hypertensive individuals, like that of normal humans, is easily saturable by ATP (≥2 µM). Analysis of the results of kinetic studies on the enzyme, in the presence of 5 mM K+, using the Hanes plot, reveals that, although the affinity (Km) of the pump for ATP is unaffected in essential hypertension, its maximum velocity (V max) is lower than in normal membranes. Even though the reason for a reduced-sodium pump function in essential hypertension is not yet clear, it may not be unconnected with the presence of an endogenous inhibitor or with genetic or diet-induced membrane defects, as previously proposed by other workers in this area of research.en_US
dc.description.sponsorshipCollege of Medicine, University of Ibadanen_US
dc.language.isoenen_US
dc.publisherBlackwell Scientific Publicationsen_US
dc.subjectHypertensionen_US
dc.titleErythrocyte membrane ouabain-sensitive Na+, K+ - ATPase of hypertensive Nigeriansen_US
dc.typeArticleen_US
Appears in Collections:African Journal of Medicine and Medical Sciences

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