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dc.contributor.authorOlaiilokiin, J. O-
dc.contributor.authorBolaj, O. M-
dc.contributor.authorAgbedaliunsi, J .M-
dc.contributor.authorOlorunsogo, O.O-
dc.date.accessioned2024-07-05T10:21:58Z-
dc.date.available2024-07-05T10:21:58Z-
dc.date.issued2012-12-
dc.identifier.citationAfr.J Med. med. Sci (2012) 41, Suppl. 27-33en_US
dc.identifier.issn1116-4077-
dc.identifier.urihttp://adhlui.com.ui.edu.ng/jspui/handle/123456789/2058-
dc.descriptionArticleen_US
dc.description.abstractMalaria , t h e most importan t parasiti c diseas e afflicting man is the leading caus e of mortality and morbidity in the world. Chemotherapy remains the mainstay for the treatment and preveitio n of the disease in the absenc e of an effective vaccine. The incidenc e of resistanc e of malari a parasite s to chemotherap y is increasing and complicated. This study w a s therefor e undertaken in order to evaluate the therapeutic effects of fractions of the stem bark of /\. boonei on P. berghei-induced malaria using chloroquine as control. Different doses (200mg/kg and 400mg/k g body weight) of methanolic extract (ME) , n-hexan e (HF) , chlorofor m (CF), ethylacetate(EF) and aqueous (AF) fractions of the stem bark of A. boonei wer e administered orally to albino mice. Five milligrammes chloroquine base per kilogramme body weight (5mg/kg bw) wa s used as positive control whil e the negative control mice received only the vehicle (5% v/v tween 80). The results obtained showe d that the 400mg/k g bw dose w a s mor e effectiv e wit h respec t to the parasit e clearanc e than the 200mg/k g bw dose. The 400mg/ kg bw dos e of M E gav e 68.1 % percent parasite clearance . T h e C F gav e the highest clearanc e of 98.8% at 40()mg/kg bw afte r 7 days treatment while chloroquin e at 5mg/k g bw gav e 100% parasite clearance. T h e orde r of increasing potency of the fractions (parasite clearance ) wa s ( EF 50.0%< A F 60.3% < H F 63.1 %, < CF 98.4%) indicating that the active principle in the stem bark wa s highest in the CF. Percentage parasitemia following exposure to these fractions also decreased in all groups in the same order and wa s only significant (p<0.05) in CF (0.11%) compared to the untreated control group. The M E of A.boonei also caused increase in P CV by 15.5%. Purification enhanced P CV value as the HF and CF fractions gave 19.0% and 24.5% increases, respectively.en_US
dc.description.sponsorshipCollege of medicineen_US
dc.language.isoenen_US
dc.publisherCollege of Medicine University of Ibadanen_US
dc.subjectMalariaen_US
dc.subjectAlstonia booneien_US
dc.subjectchemotherapyen_US
dc.subjectpercentage clearanceen_US
dc.subjectchloroquineen_US
dc.subjectmiceen_US
dc.titleTherapeutic effects of various solvent fractions of alstonia boonei (apocynaceae) stem bark on Plasmodium berghei-induced malariaen_US
dc.typeArticleen_US
Appears in Collections:African Journal of Medicine and Medical Sciences

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