Please use this identifier to cite or link to this item: http://adhlui.com.ui.edu.ng/jspui/handle/123456789/2097
Title: A new understanding of goitrogenesis: role of cytokines in the regulation of normal and aberrant thyroid growth
Authors: DAGOGO-JACK, SAM
Keywords: goitrogenesis
thyroid
growth
Issue Date: Sep-1995
Publisher: SPECTRUM BOOKS LIMITED.
Citation: Afr.J. Med. med. Sci. (1995) 24, 211-217
Abstract: Several cytokines and growth factors together with their binding proteins and/or receptors arc being increasingly detected in mammalian thyroid tissue. These include epidermal growth factor, insulin-like growth factors, transforming growth factors, fibroblast growth factor, intcrlcukins, interferons, and tumour necrosis factor-alpha. Their exact role in relation to thyroid regulation has not been fully elucidated but it is clear that many of these peptide regulatory factors arc mitogcnic for cultured thyrocytes. Recent evidence suggests that some thyroid cancers and benign goiters over-express receptors for a number of these growth factors. Transforming growth factor-beta is unique for its dominant anti-proliferative effect on thyrocytes concurrently exposed to potent thyroid mitogens. The mammalian thyroid cell is clearly a source as well as target of myriad polypeptide factors that probably co-regulate its normal growth and differentiation. Aberrant expression of these growth factors or their receptors might be a factor in the development of goiter.
Description: Article
URI: http://adhlui.com.ui.edu.ng/jspui/handle/123456789/2097
ISSN: 1116-4077
Appears in Collections:African Journal of Medicine and Medical Sciences

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