Please use this identifier to cite or link to this item: http://adhlui.com.ui.edu.ng/jspui/handle/123456789/2157
Title: Non-specific bronchial airway hyperreactivity and the diagnosis of asthma
Authors: OLUBOYO, P. O
HEATON, R. W
COSTELLO, J. F
Keywords: asthma
bronchial airway
bronchial inhalation
Nigerians
Issue Date: 1989
Publisher: BLACKWELL SCIENTIFIC PUBLICATIONS
Citation: Afr. J. Med. med. Sci. (1989) 18:55-61
Abstract: In very mild and atypical eases of asthma, highly discriminative tests are needed to make the diagnosis. To demonstrate this, measurement of non-specific bronchial airway hyperreactivity by means of standardized bronchial inhalation challenge tests with histamine and methachoiine were performed in 10 very mild asthmatic and nine normal control subjects; both groups included Nigerians who were temporarily resident in London at the time of the study. Bronchial reactivity was expressed as the provocative concentration of the agents causing a 20% fall in forced expiratory volume in 1 sec (PC20FEV,); higher values indicating lower levels of non-specific bronchial reactivity. The level of non-specific bronchial reactivity in these very mild asthmatics, whose baseline physiological data were not different from those in normals, was found to be 18-29 times higher than the normal control subjects. These tests very effectively discriminated between asthmatic and normal control subjects. With available resources it should be possible to study a large number of Nigerians in their own environment
Description: Article
URI: http://adhlui.com.ui.edu.ng/jspui/handle/123456789/2157
ISSN: 1116-4077
Appears in Collections:African Journal of Medicine and Medical Sciences

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