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dc.contributor.authorArinola, O.G-
dc.contributor.authorLouis, J-
dc.contributor.authorTacchini-Cottier, F-
dc.contributor.authorAseffa, A-
dc.contributor.authorSalimonu, L.S-
dc.date.accessioned2024-07-17T12:28:59Z-
dc.date.available2024-07-17T12:28:59Z-
dc.date.issued2005-
dc.identifier.citationAfr. J. Med. rned. Sci. 2005: 34. 65-70en_US
dc.identifier.issn1116-4077-
dc.identifier.urihttp://adhlui.com.ui.edu.ng/jspui/handle/123456789/2179-
dc.description.abstractTo determine if gestational factors affect the severity of L. major infection, this study assessed the levels of IL-4 mRNA and IFN-gamma mRNA in popliteal lymph node cells of pregnant C57BL/6 mice mated at 5hours, 16hours and 15days post L. major infection using PCR. Infected pregnant C57BL/ 6 mice developed larger cutaneous footpad lesions compared with non-pregnant infected C57BL/6 mice. The resolution of footpad lesions commenced after 8th week in C57BL/6 mice mated at 16hrs post L. major infection but 12 weeks in C57BL/ 6 mice mated at 5hrs and 15 days post L. major infection. C57BL/6 mice that were infected 20 days post partum resolved L. major infection effectively. But, the lesions in infected pregnant C57BL/6 mice and infected non-pregnant C57BL/6 mice were not as large as in susceptible BALB/c mice. The mean litter weights were similar in pregnant infected C57BL/6 mice mated at different stages of L. major infection but were slightly lower than weights of litters from pregnant uninfected C57BL/6 mice. In 5 days infected pregnant C57BL/6 mice, the levels of IFN-gamma were raised compared with the levels of IL-4 but those mated at 15 days post L. major infection had highest level of IFN-gamma mRNA. In 10 days pregnant infected C57BL/6 mice, levels of IL-4 were raised compared with IFN-gamma but mice mated at 16hrs post L. major infection had highest level of IL-4. In 15 days pregnant infected mice, the levels of IL-4 were higher than IFN-gamma irrespective of the stage of L. major infection when the mice were mated. Mice infected with L. major 20 days post-partum produced more IFN-gamma than IL-4 from 16hrs post L. major infection onwards. It may be concluded that increased IL-4 in pregnant infected C57BL/6 mice impairs the resistance of C57BL76 mice to L. major infection especially in mice that were pregnant before effective immunity (5 hours post L. major infection) is mounted against L. major infectionen_US
dc.description.sponsorshipCollege of Medicine, University of Ibadanen_US
dc.language.isoenen_US
dc.publisherCollege of Medicineen_US
dc.subjectCytokines,en_US
dc.subjectMice, L. majoren_US
dc.subjectGestationen_US
dc.subjectPregnancy outcomes.en_US
dc.titlePregnancy impairs resistance of C57BL/6 mice to Leishmania major infectionen_US
dc.typeArticleen_US
Appears in Collections:African Journal of Medicine and Medical Sciences

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