Analgesic activity of aqueous leaf extract of Phyllanthus Amarus

Please use this identifier to cite or link to this item: http://adhlui.com.ui.edu.ng/jspui/handle/123456789/2925

Title:	Analgesic activity of aqueous leaf extract of Phyllanthus Amarus
Authors:	Iranloye, B.O Owoyele, V.B Kelani, O.R Olaleye, S.B
Keywords:	Phyllanthus amarus; Pnalgesic Pain Anti-inflammatory
Issue Date:	2011
Publisher:	COLLEGE OF MEDICINE, UNIVERSITY OF IBADAN, NIGERIA
Citation:	Afr. J. Med. med. Sci. (2011) 40, 47-50
Abstract:	Various doses of the aqueous extract of Phyllanthus amarus (AEPA) were investigated for analgesic and anti-inflammatory activities using both thermal and chemical models of pain assessment in rats. The extract caused a significant (P< 0.05) dose related increase inhibition of the carrageenan-induced paw oedema in the rats. The inhibition produced by 200mg/kg AEPA (70.20%) was significantly higher than that of the reference drug (Acetylsalicylic acid). The extract produced a marked analgesic activity by inhibiting both early and late phases of pain stimulus in Formalininduced paw licking rats and also a significant and dose related increase in inhibiting the mean tail immersion duration (MITD) at varying water bath temperature (50°C, 55°C and COX). This study thus established the anti-inflammatory and analgesic activities of Phyllanthus amarus.
Description:	Article
URI:	http://adhlui.com.ui.edu.ng/jspui/handle/123456789/2925
ISSN:	1116-4077
Appears in Collections:	African Journal of Medicine and Medical Sciences

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