Abnormal haemoglobin variants, ABO and rhesus blood group distribution among pregnant women in a ve.latum?; secondary health centre in Ibadan, South West Nigeria

Abstract

The distribution of the ABO and Rh and abnormal haemoglobin variants will determine the blood type and slock levels in hospital blood banks. This study determined the prevalence of haemoglobin variants, ABO and RhD blood group distribution among pregnant women at a secondary level hospital in Nigeria. Methodology - I his was a cross sectional study of health y pregnan t wome n attending Adeoyo Maternity Hospital, Ibadan, Nigeria. The record of every woman presenting for their first antenatal clinic visit over a 4-month period was reviewed. This included the results of haemoglobin electrophoresis and blood group. Results - Thirty four records were excluded because of incomplete data. The results for 2664 women are presented. The majority (70.1%) had normal haemoglobin (Mb AA), 29.5% were heterozygous for A (AS, AC) while 0.4% had abnormal Mb variants (SS, CC. SC). Rhesus D positive rate was 93.6%. Almost half (48.1%) were of blood group O, blood groups A and B were 23.5% vs. 24.9% respectively. The least blood group wa s AB. The ABO gene frequencies among these pregnant women were 0>B>A>AB. The phenotype frequencies with respect to ABO and Rhesus system were: O' > B > A > 0 > AB > A > B > AB