The antihyperglycamic effect of Telfaria occidentalis in mice

Abstract

The hypoglycemic effect of Telfaria occidentalis was studied in mice. The effect of the aqueous extract of the leaves on blood glucose level were assessed in normoglycemic, glucose induced hyperglycemic and streptozotocin (STZ) induced diabetic mice. The aqueous extract given orally in 1 g/kg did not alter the blood glucose level in normoglycemic mice. In glucose-induced hyperglycemia, antidiabetic activity was seen when the extract and glucose were administered simultaneously and when the extract was giving to the mice 60 minutes before glucose. In STZ-induced diabetic mice, a reduction in the blood glucose level was seen from day two of the administration of the extract. The hypoglycemic effect of the aqueous extract was compared with that of an oral dose of chlorpropamide (200 mg/kg) under the same conditions. The results of this study indicate that the aqueous extract of the leaves of Telfaria occidentalis possess hypoglycemic activity.